Anti-Dystrophia myotonica protein kinase / DMPK antibody (ab102804)
Key features and details
- Rabbit polyclonal to Dystrophia myotonica protein kinase / DMPK
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Dystrophia myotonica protein kinase / DMPK antibody
See all Dystrophia myotonica protein kinase / DMPK primary antibodies -
Description
Rabbit polyclonal to Dystrophia myotonica protein kinase / DMPK -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human Dystrophia myotonica protein kinase/ DMPK aa 1-629.
Database link: NP_004400.4 -
Positive control
- WB: HeLa and Dystrophia myotonica protein kinase / DMPK transfected 293T cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab102804 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 70 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 70 kDa. |
Target
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Function
Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban. -
Tissue specificity
Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. -
Involvement in disease
Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats. -
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain. - Information by UniProt
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Database links
- Entrez Gene: 1760 Human
- Omim: 605377 Human
- SwissProt: Q09013 Human
- Unigene: 631596 Human
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Alternative names
- DM 1 antibody
- DM antibody
- DM kinase antibody
see all
Images
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Anti-Dystrophia myotonica protein kinase / DMPK antibody (ab102804) at 1/500 dilution + HeLa cell lysate at 50 µg
Predicted band size: 70 kDa -
All lanes : Anti-Dystrophia myotonica protein kinase / DMPK antibody (ab102804) at 1/500 dilution
Lane 1 : Dystrophia myotonica protein kinase / DMPK transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell line
Lysates/proteins at 25 µg per lane.
Predicted band size: 70 kDa
Datasheets and documents
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Datasheet download
References (0)
ab102804 has not yet been referenced specifically in any publications.