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Product Name
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E Cadherin protein (Tagged)
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Product type
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Proteins and Peptides
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Peptide
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Recombinant fusion protein fragment (fused to a proprietary tag), corresponding to amino acids 600-707 of Human E Cadherin
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Tested applications
(see key)
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ELISA, Inhib, SDS-PAGE, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent concentration.
Inhib: Use at a concentration of 5 - 10 µg/ml.
SDS-PAGE: Use at a concentration of 0.1 - 1 µg/ml.
WB: Use at an assay dependent dilution. Detects a band of approximately 38 kDa (predicted molecular weight: 97 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Developmental Biology >> Organogenesis >> Excretory system development >> Kidney development
Cancer >> Invasion/microenvironment >> ECM >> Cell adhesion >> Cadherins
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Binding Proteins
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cadherins
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Relevance
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One of the epithelial cell adhesion molecules, E Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcimomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E Cadherin expression. Therefore, the expression of E Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm.
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Purity
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Purified via His tag
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Storage buffer
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Preservative: None
Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Expression system
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E. coli
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this E Cadherin protein (Tagged) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to E Cadherin
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