EAAT2 antibody (ab58571)

Product Name 

EAAT2 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to EAAT2

Immunogen 

Synthetic peptide: NGKSADCSVEEEPWKREK) (Rat), corresponding to amino acids at the C-terminus of EAAT2.
BLAST 'NGKSADCSVEEEPWKREK)' with or

Reacts with 

Rat

Predicted to react 
(species key)

Hu, Ms, Chmp, Dog, RMk, Orngt
(Due to sequence homology)

Specificity 

This antibody recognizes the ~75 kDa and the ~50 kDa forms of EAAT2. This antibody may also cross react non-specifically with a ~102 kDa protein not believed to be related to EAAT2.

Tested applications 
(see key)

IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
IP: Use at an assay dependent dilution.
WB: 1/1000. Predicted molecular weight: 62 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Multi-pass membrane protein

Research areas 

Neuroscience >> Neurotransmitter >> Amino Acids >> Glutamate

Relevance 

EAAT2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Supplied as Serum diluted in PBS.

Form 

Liquid

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

References for EAAT2 antibody (ab58571)

  This product has been used in:

Sama MA et al. Interleukin-1{beta}-dependent Signaling between Astrocytes and Neurons Depends Critically on Astrocytic Calcineurin/NFAT Activity. J Biol Chem 283:21953-64 (2008). WB; Rat. PubMed: 18541537

If you publish research using ab58571 please let us know so that we can cite the reference on this datasheet.

Customer reviews (feedback) regarding EAAT2 antibody

Customer FAQs regarding EAAT2 antibody

Protocols for EAAT2 antibody

Price and availability of products related to EAAT2 antibody

EAAT2 antibody - related products: