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Overview

  • Product nameEBI3 proteinSee all EBI3 proteins and peptides ...
  • Protein descriptionRecombinant full length Human EBI3 (amino acids 1-229) fused at the C-terminus to the Fc portion of human IgG1, 60 kDa. (UniProt ID = Q14213).
  • Uniprot accessionQ14213
  • Molecular weight60kDa
  • Protein length229 amino acids
  • Expression hostHEK 293 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab108953 is 0.2µm filtered.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab108953 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        cytokine receptorEBI3EBV induced gene 3 protein
        EBV-induced gene 3 proteinEpstein Barr virus induced 3Epstein Barr virus induced gene 3Epstein Barr virus induced gene 3 proteinEpstein-Barr virus-induced gene 3 proteinIL 27 subunit betaIL 27BIL-27 subunit betaIL-27BIL27 subunitIL27 subunit betaIL27BIL27B_HUMANIL35 subunitinterleukin 27 subunit betaInterleukin-27 subunit beta
      see all
  • FunctionCytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 2 fibronectin type-III domains.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession Q14213 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for EBI3 protein (ab108953)

    ab108953 has not yet been referenced specifically in any publications.

    Publishing research using ab108953 ? Please let us know so that we can cite the reference in this datasheet

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