Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab45974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • EBP 50
    • EBP50
    • Ezrin radixin moesin binding phosphoprotein 50
    • Ezrin-radixin-moesin-binding phosphoprotein 50
    • Na(+)/H(+) exchange regulatory cofactor NHE RF
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    • Na+/H+ exchange regulatory co factor
    • NHERF
    • NHERF 1
    • NHERF-1
    • NHERF1
    • NHRF1_HUMAN
    • NPHLOP2
    • Regulatory cofactor of Na(+)/H(+) exchanger
    • SLC9A3R1
    • Sodium hydrogen exchanger regulatory factor 1
    • Sodium-hydrogen exchanger regulatory factor 1
    • Sodium/hydrogen exchanger regulatory factor 1
    • Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1
    • Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform 3 regulatory factor 1
    • Solute carrier family 9 isoform A3 regulatory factor 1
    • Solute carrier family 9 member 3 regulator 1
    see all
  • FunctionScaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
  • Tissue specificityDetected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
  • Involvement in diseaseDefects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).
  • Sequence similaritiesContains 2 PDZ (DHR) domains.
  • Post-translational
    modifications
    Phosphorylated on serine residues.
  • Cellular localizationCytoplasm. Apical cell membrane. Endomembrane system. Cell projection > filopodium. Cell projection > ruffle. Cell projection > microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.
  • Target information above from: UniProt accession O14745 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for EBP50 peptide (ab45974)

ab45974 has not yet been referenced specifically in any publications.

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