Overview
Product nameEBP50 peptideSee all EBP50 proteins and peptides ...
Protein descriptionSynthetic peptide derived from within residues 250 - 350 of Human EBP50.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab45853 - EBP50 antibody.
Protein length358 amino acids
Properties
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab45853.
Protein info
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Alternative names
EBP 50EBP50Ezrin radixin moesin binding phosphoprotein 50
Ezrin-radixin-moesin-binding phosphoprotein 50Na(+)/H(+) exchange regulatory cofactor NHE RFNa(+)/H(+) exchange regulatory cofactor NHE-RF1Na+/H+ exchange regulatory co factorNHERFNHERF 1NHERF-1NHERF1NHRF1_HUMANNPHLOP2Regulatory cofactor of Na(+)/H(+) exchangerSLC9A3R1Sodium hydrogen exchanger regulatory factor 1Sodium-hydrogen exchanger regulatory factor 1Sodium/hydrogen exchanger regulatory factor 1Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1Solute carrier family 9 isoform 3 regulatory factor 1Solute carrier family 9 isoform A3 regulatory factor 1Solute carrier family 9 member 3 regulator 1
see all
FunctionScaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
Tissue specificityDetected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
Involvement in diseaseDefects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).
Sequence similaritiesContains 2 PDZ (DHR) domains.
Post-translational
modificationsPhosphorylated on serine residues.
Cellular localizationCytoplasm. Apical cell membrane. Endomembrane system. Cell projection > filopodium. Cell projection > ruffle. Cell projection > microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells.
References for EBP50 peptide (ab45974)
ab45974
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
