Anti-EBV Nuclear Antigen antibody  (ab20777)
- Product nameAnti-EBV Nuclear Antigen antibody See all EBV Nuclear Antigen primary antibodies ...
- DescriptionMouse monoclonal  to EBV Nuclear Antigen
- SpecificitySpecific for the EB nuclear antigen 1 (EBNA1).
- Tested applicationsWB, IP, IHC-Fr more details
- Species reactivityReacts with EBV. Not yet tested in other species.
Recombinant full length protein. EB nuclear antigen 1.
- EpitopeReacts with the carboxy terminus (last 100aa) of the molecule.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.1% Sodium Azide
Constituents: 0.01M PBS, pH 7.2
- Concentration information loading...
- PurityProtein A purified
- Clonality Monoclonal
- Clone number0211
- Research Areas
Our Abpromise guarantee covers the use of ab20777 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use at an assay dependent dilution. Detects a band of approximately 70 kDa.|
|IP||IP: Use at an assay dependent dilution.|
|IHC-Fr||IHC-Fr: Use at an assay dependent dilution. Fix with methanol/acetone.|
- RelevanceEpstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
- Cellular localizationNuclear. Free in the nucleoplasm, somewhat associated with the chromatin and hardly, if at all associated with the nuclear matrix.
- EBNA1 antibodyEBV nuclear antigen 1 antibodyEpstein Barr nuclear antigen 1 antibody
- Epstein Barr virus antibodyHHV4 antibodyHuman Herpesvirus 4 antibody
References for Anti-EBV Nuclear Antigen antibody  (ab20777)
This product has been referenced in:
- Onnis A et al. Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma. Blood Cancer J 2:e84 (2012). ICC/IF ; Human . Read more (PubMed: 22941339) »