Anti-EBV Nuclear Antigen antibody [0211] (ab20777)

Overview

  • Product nameAnti-EBV Nuclear Antigen antibody [0211]See all EBV Nuclear Antigen primary antibodies ...
  • Description
    Mouse monoclonal [0211] to EBV Nuclear Antigen
  • SpecificitySpecific for the EB nuclear antigen 1 (EBNA1).
  • Tested applicationsWB, IP, IHC-Fr more details
  • Species reactivity
    Reacts with EBV. Not yet tested in other species.
  • Immunogen

    Recombinant full length protein. EB nuclear antigen 1.

  • EpitopeReacts with the carboxy terminus (last 100aa) of the molecule.

Properties

Applications

Our Abpromise guarantee covers the use of ab20777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use at an assay dependent dilution. Detects a band of approximately 70 kDa.
IP Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent dilution. Fix with methanol/acetone.

Target

  • RelevanceEpstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
  • Cellular localizationNuclear. Free in the nucleoplasm, somewhat associated with the chromatin and hardly, if at all associated with the nuclear matrix.
  • Alternative names
    • EBNA1 antibody
    • EBV nuclear antigen 1 antibody
    • Epstein Barr nuclear antigen 1 antibody
    • Epstein Barr virus antibody
    • HHV4 antibody
    • Human Herpesvirus 4 antibody
    see all

References for Anti-EBV Nuclear Antigen antibody [0211] (ab20777)

This product has been referenced in:
  • Zhang A  et al. RNase L restricts the mobility of engineered retrotransposons in cultured human cells. Nucleic Acids Res 42:3803-20 (2014). ICC/IF . Read more (PubMed: 24371271) »
  • Onnis A  et al. Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma. Blood Cancer J 2:e84 (2012). ICC/IF . Read more (PubMed: 22941339) »

See all 2 Publications for this product

Product Wall

Thank you for your enquiry and your interest in our product. I can confirm that ab20777 has been tested in WB, IP, IHC-Fr but we have no data yet for Flow cytometry. Therefore it is not known if this antibody is suitable for this specific applicati...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"