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Anti-EDAR antibody [RM0077-8L53] (ab86051)

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Overview

Product name

Anti-EDAR antibody [RM0077-8L53]
See all EDAR products (3) ...

Description

Rat monoclonal [RM0077-8L53] to EDAR

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Mouse recombinant extracellular domain of EDAR.

Properties

Form

Liquid

Storage instructions

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Purification notes

The IgG fraction of culture supernatant was purified by Protein A affinity chromatography and lyophilized from a 0.2 µm filtered solution.

Clonality

Monoclonal

Clone number

RM0077-8L53

Isotype

IgG2

Research areas

Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> NFkB pathway
Signal Transduction >> Growth Factors/Hormones >> TNF
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway

Applications

Show applications key

Our Abpromise guarantee covers the use of ab86051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: 1/500 - 1/1000.Predi...Read more →

    WB: 1/500 - 1/1000.Predicted molecular weight: 49 kDa.

Target

Relevance

EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.

Cellular localization

Membrane; Single pass type I membrane protein

Alternative names

  • Anhidrotic ectodysplasin receptor 1 antibody
  • DL antibody
  • Downless (mouse) homolog antibody
  • Downless homolog antibody
  • Downless mouse homolog of antibody
  • Ectodermal dysplasia receptor antibody
  • Ectodysplasin 1 anhidrotic receptor antibody
  • Ectodysplasin A receptor antibody
  • ED 1R antibody
  • ED 3 antibody
  • ED 5 antibody
  • ED1R antibody
  • ED3 antibody
  • ED5 antibody
  • EDA 1R antibody
  • EDA 3 antibody
  • EDA A1 receptor antibody
  • EDA A1R antibody
  • EDA1R antibody
  • EDA3 antibody
  • Tumor necrosis factor receptor superfamily member EDAR antibody
see all

Database links

References for Anti-EDAR antibody [RM0077-8L53] (ab86051)

ab86051 has not yet been referenced specifically in any publications.

Publishing research using ab86051? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"