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Western blot - EDAR antibody (ab56803)
Western blot - EDAR antibody (ab56803)
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Product Name 

EDAR antibody

 

See all EDAR antibodies (3)...

Product type 

Primary antibodies

Description 

Mouse monoclonal to EDAR

Immunogen 

Recombinant fragment, corresponding to amino acids 64-179 of Human EDAR

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB


Abreviews 

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Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Single pass type I membrane protein

Research areas 

Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> NFkB pathway
Signal Transduction >> Growth Factors/Hormones >> TNF
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway

Relevance 

EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.

 

Alternative names EDAR antibody (ab56803)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

10913    (Human)

Omim

    

604095    (Human)

SwissProt

    

Q9UNE0    (Human)

Raised in 

Mouse

Clonality 

Monoclonal

Isotype 

IgG2b

Light chain type 

kappa

Purity 

Protein G purified

Storage buffer 

Preservative: None
PBS, pH 7.2

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this EDAR antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

EDAR antibody images:

Product image  Western blot - EDAR antibody (ab56803)

Western blot - EDAR antibody (ab56803)

Western blot against tagged recombinant protein immunogen using ab56803 EDAR antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa

 
 

Search PubMed (MEDLINE) for references to EDAR

 

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