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Products:Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Overview
Product name
Anti-EDAR antibody
See all EDAR products (3) ...
Description
Mouse monoclonal to EDAR
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 64-179 of Human EDAR
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2b
Light chain type
kappa
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Western blot - EDAR antibody (ab56803)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56803 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.
Cellular localization
Membrane; Single pass type I membrane protein
Alternative names
- Anhidrotic ectodysplasin receptor 1 antibody
- DL antibody
- Downless (mouse) homolog antibody
see all
Database links
- Entrez Gene: 10913 Human
- Omim: 604095 Human
- SwissProt: Q9UNE0 Human
Anti-EDAR antibody images:
Western blot - EDAR antibody (ab56803)
Western blot against tagged recombinant protein immunogen using ab56803 EDAR antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa
References for Anti-EDAR antibody (ab56803)
ab56803 has not yet been referenced specifically in any publications.
Publishing research using ab56803? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"