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Products:Cell Biology >> Apoptosis >> Receptors >> Associated Proteins
Overview
Product name
Anti-EDG1 antibody
See all EDG1 products (8) ...
Description
Mouse monoclonal to EDG1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKL, corresponding to amino acids 1-48 of Human EDG1
MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKL
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG1
Light chain type
kappa
Research areas
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cell Adhesion Molecules >> Endothelial
Cell Biology >> Apoptosis >> Receptors >> Associated Proteins
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Western blot - EDG1 antibody (ab54948)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54948 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Tissue specificity
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Post-translational
modifications
S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP21453
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD363 antibody
- CHEDG 1 antibody
- CHEDG1 antibody
see all
Database links
- Entrez Gene: 1901 Human
- Omim: 601974 Human
- SwissProt: P21453 Human
- Unigene: 154210 Human
Anti-EDG1 antibody images:
Western blot - EDG1 antibody (ab54948)
EDG1 antibody (ab54948) at 1ug/lane + Jurkat cell lysate at 25ug/lane.
References for Anti-EDG1 antibody (ab54948)
ab54948 has not yet been referenced specifically in any publications.
Publishing research using ab54948? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"