EDG4 antibody (ab13349)

Product Name 

EDG4 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to EDG4

Immunogen 

Synthetic peptide conjugated to KLH. (Unfortunately, the amino acid sequence is considered to be commercially sensitive).

Reacts with 
(species key)

Hu

Epitope 

3rd cytoplasmic loop

Tested applications 
(see key)

ICC, IHC-P

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
ICC: Use at an assay dependent dilution.
IHC-P: 1/100 - 1/200.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Plasma membrane

Research areas 

Chromatin and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> LIM
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other

Relevance 

EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor, and leukocyte containing tissues.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: PBS, pH 7.7

Purification notes 

The antibody is purified on a peptide immunogen afinity column

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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EDG4 antibody images:

References for EDG4 antibody (ab13349)

  This product has been used in:

Dottori M et al. Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26:1146-54 (2008). ICC/IF; Human. PubMed: 18308941

If you publish research using ab13349 please let us know so that we can cite the reference on this datasheet.

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