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Products:Epigenetics and Nuclear Signaling >> Chromatin Remodeling >> Polycomb Silencing >> PRC1
Overview
Product name
Anti-EDR1 / PHC1 antibody
See all EDR1 / PHC1 products (3) ...
Description
Mouse monoclonal to EDR1 / PHC1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: PVGCSQLLKE SEKPLQTGLP TGLTENQSGG PLGVDSPSAE LDKKANLLKC EYCGKYAPAE QFRGSKRFCS MTCAKRYNVS CSHQFRLKRK KMKEFQEANY , corresponding to amino acids 751-851 of Human EDR1 / PHC1
PVGCSQLLKE SEKPLQTGLP TGLTENQSGG PLGVDSPSAE LDKKANLLKC EYCGKYAPAE QFRGSKRFCS MTCAKRYNVS CSHQFRLKRK KMKEFQEANY
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2b
Light chain type
kappa
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Western blot - EDR1 / PHC1 antibody (ab54954)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54954 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. PHC1 is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. PHC1, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Cellular localization
Nuclear
Alternative names
- Early development regulatory protein 1 antibody
- hPH1 antibody
- EDR1 PH1 antibody
see all
Database links
- Entrez Gene: 1911 Human
- Omim: 602978 Human
- SwissProt: P78364 Human
Anti-EDR1 / PHC1 antibody images:
Western blot - EDR1 / PHC1 antibody (ab54954)
Western blot against tagged recombinant protein immunogen using ab54954 EDR1 / PHC1 antibody at 1ug/ml. Predicted band size of immunogen is 43 kDa
References for Anti-EDR1 / PHC1 antibody (ab54954)
ab54954 has not yet been referenced specifically in any publications.
Publishing research using ab54954? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"