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Anti-EGF antibody [1B11-3E12] (ab40644)

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Overview

Product name

Anti-EGF antibody [1B11-3E12]
See all EGF products (16) ...

Description

Mouse monoclonal [1B11-3E12] to EGF

Specificity

This antibody does not react with TGFalpha, human IGF-1 or human IGF-2.

Tested applications

ICC/IF, WB, Indirect ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein (Human)

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

1B11-3E12

Isotype

IgG1

Light chain type

kappa

Research areas

Cancer >> Growth factors >> EGF
Signal Transduction >> Growth Factors/Hormones >> EGF

Applications

Show applications key

Our Abpromise guarantee covers the use of ab40644 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ICC/IF

     ICC/IF: 1/50

    ICC/IF: 1/50

  • ShowHide

    WB

     WB: 1/50Detects a band o...Read more →

    WB: 1/50Detects a band of approximately 6.2 kDa.(Blocking with 5% goat or donkey serum significantly reduces background when compared with BSA or milk blocking.)

  • Indirect ELISA

     I-ELISA: 1/400

    I-ELISA: 1/400

Target

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.

Tissue specificity

Expressed in kidney, salivary gland, cerebrum and prostate.

Involvement in disease

Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.

Sequence similarities

Contains 9 EGF-like domains.
Contains 9 LDL-receptor class B repeats.

Cellular localization

Membrane.

Target information above from: UniProt accessionP01133 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Beta urogastrone antibody
  • Beta urogastrone antibody
  • EGF antibody
  • Egf antibody
  • EGF_HUMAN antibody
  • Epidermal Growth Factor antibody
  • Epidermal Growth Factor antibody
  • HOMG4 antibody
  • OTTHUMP00000219721 antibody
  • OTTHUMP00000219722 antibody
  • Pro epidermal growth factor antibody
  • URG antibody
  • URG antibody
  • Urogastrone antibody
  • Urogastrone antibody
see all

Database links

References for Anti-EGF antibody [1B11-3E12] (ab40644)

ab40644 has not yet been referenced specifically in any publications.

Publishing research using ab40644? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"