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Anti-EGF antibody (Biotin) (ab84263)

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Overview

Product name

Anti-EGF antibody (Biotin)
See all EGF products (16) ...

Description

Rabbit polyclonal to EGF (Biotin)

Conjugation

Biotin

Tested applications

ELISA, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Highly pure (>98%) recombinant human EGF

Properties

Form

Lyophilised:
Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS, pH 7.2

Concentration

Concentration information loading...

Purification notes

ab84263 is affinity purified and sterile filtered.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Growth factors >> EGF
Signal Transduction >> Growth Factors/Hormones >> EGF

Applications

Show applications key

Our Abpromise guarantee covers the use of ab84263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    ELISA

     ELISA: Use a concentrati...Read more →

    ELISA: Use a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2-0.4 ng/well of recombinant human EGF.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 134 kDa.

Target

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.

Tissue specificity

Expressed in kidney, salivary gland, cerebrum and prostate.

Involvement in disease

Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.

Sequence similarities

Contains 9 EGF-like domains.
Contains 9 LDL-receptor class B repeats.

Cellular localization

Membrane.

Target information above from: UniProt accessionP01133 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Beta urogastrone antibody
  • EGF antibody
  • Egf antibody
  • EGF_HUMAN antibody
  • Epidermal Growth Factor antibody
  • HOMG4 antibody
  • OTTHUMP00000219721 antibody
  • OTTHUMP00000219722 antibody
  • Pro epidermal growth factor antibody
  • URG antibody
  • Urogastrone antibody
see all

Database links

References for Anti-EGF antibody (Biotin) (ab84263)

ab84263 has not yet been referenced specifically in any publications.

Publishing research using ab84263? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"