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Product name
Anti-EGF antibody [RM0078-2M13]
See all EGF products (16) ...
Description
Rat monoclonal [RM0078-2M13] to EGF
Tested applications
Cross reactivity
Reacts with
Mouse
Immunogen
Mouse recombinant EGF
Properties
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
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Purity
Protein A purified
Purification notes
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography and filter sterilized.
Clonality
Monoclonal
Clone number
RM0078-2M13
Isotype
IgG2
Research areas
Cancer >> Growth factors >> EGF
Signal Transduction >> Growth Factors/Hormones >> EGF
Applications
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Our Abpromise guarantee covers the use of ab86052 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000. Predicted molecular weight: 134 kDa.
Target
Function
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Tissue specificity
Expressed in kidney, salivary gland, cerebrum and prostate.
Involvement in disease
Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.
Sequence similarities
Contains 9 EGF-like domains.
Contains 9 LDL-receptor class B repeats.
Cellular localization
Membrane.
Target information above from: UniProt accessionP01133
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Beta urogastrone antibody
- EGF antibody
- Egf antibody
see all
Database links
- Entrez Gene: 13645 Mouse
- SwissProt: Q8VD07 Mouse
- SwissProt: Q3UWD7 Mouse
- SwissProt: Q569W5 Mouse
- SwissProt: P01132 Mouse
- Unigene: 252481 Mouse
References for Anti-EGF antibody [RM0078-2M13] (ab86052)
ab86052 has not yet been referenced specifically in any publications.
Publishing research using ab86052? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"