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Anti-EID1 antibody (ab14454)

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Overview

Product name

Anti-EID1 antibody
See all EID1 products (2) ...

Description

Rabbit polyclonal to EID1

Tested applications

IP, WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse

Immunogen

Synthetic peptide: GSGSRELSLRPSRSGA conjugated to KLH, corresponding to C terminal amino acids 34-49 of Human EID1.

GSGSRELSLR PSRSGA

Positive control

EID1 transfected Cos1 cell lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 30% Glycerol, 0.15M Sodium chloride, 0.1M Tris glycine. pH 7.4

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    IP

     IP: Use a concentration ...Read more →

    IP: Use a concentration of 10 µg/ml

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 2 - 4 µg/ml.Predicted molecular weight: 22 kDa.

Target

Function

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Tissue specificity

Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A549 and various leukemia cell lines.

Developmental stage

Expression decreased with development in ventricular tissue while remaining highly expressed in adult atrial tissue. In primary cultures of human skeletal myocytes, expression decreased during myogenic differentiation (at protein level).

Post-translational
modifications

Ubiquitinated in U-2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.

Cellular localization

Nucleus. Cytoplasm. May shuttle between nucleus and cytoplasm.

Target information above from: UniProt accessionQ9Y6B2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 21 kDa pRb associated protein antibody
  • 21 kDa pRb-associated protein antibody
  • C15orf3 antibody
  • CBP antibody
  • Chromosome 15 open reading frame 3 antibody
  • CREBBP/EP300 inhibitor 1 antibody
  • CREBBP/EP300 inhibitory protein 1 antibody
  • CRI 1 antibody
  • CRI1 antibody
  • E1A like inhibitor of differentiation antibody
  • E1A-like inhibitor of differentiation 1 antibody
  • EID 1 antibody
  • EID-1 antibody
  • EID1 antibody
  • EID1_HUMAN antibody
  • EP300 interacting inhibitor of differentiation 1 antibody
  • EP300-interacting inhibitor of differentiation 1 antibody
  • IRO45620 antibody
  • MGC138883 antibody
  • MGC138884 antibody
  • NB4 apoptosis related protein antibody
  • PNAS 22 antibody
  • PNAS22 antibody
  • PTD014 antibody
  • Rb and p300 binding protein EID 1 antibody
  • Rb and p300 binding protein EID1 antibody
  • RBP21 antibody
  • Retinoblastoma protein associated protein antibody
see all

References for Anti-EID1 antibody (ab14454)

ab14454 has not yet been referenced specifically in any publications.

Publishing research using ab14454? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"