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Anti-ERG antibody (ab87105)

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Overview

Product name

Anti-ERG antibody
See all ERG products (7) ...

Description

Rabbit polyclonal to ERG

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Chicken, Cow

Immunogen

Synthetic peptide corresponding to a region within internal sequence amino acids 360-409 (IMTKVHGKRY AYKFDFHGIA QALQPHPPES SLYKYPSDLP YMGSYHAHPQ) of Human ERG (NP_004440).

Positive control

Human fetal liver lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 2% Sucrose, PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - ERG antibody (ab87105)Western blot - ERG antibody (ab87105) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab87105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Involvement in disease

Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.
Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.

Sequence similarities

Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.

Cellular localization

Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Target information above from: UniProt accessionP11308 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Avian erythroblastosis virus E-26 (v-ets) oncogene related antibody
  • D030036I24Rik antibody
  • Erg 3 antibody
  • Erg antibody
  • ERG/EWS fusion gene, included antibody
  • ERG/FUS fusion gene, included antibody
  • ERG/TMPSSR2 fusion gene, included antibody
  • ERG_HUMAN antibody
  • ERG1, included antibody
  • ERG2, included antibody
  • ETS-related gene antibody
  • KCNH2 antibody
  • Oncogene ERG antibody
  • p55 antibody
  • Transcriptional regulator ERG antibody
  • Transforming protein ERG antibody
  • v ets avian erythroblastosis virus E26 oncogene antibody
  • v ets avian erythroblastosis virus E26 oncogene related antibody
  • v ets erythroblastosis virus E26 oncogene homolog antibody
  • v ets erythroblastosis virus E26 oncogene like antibody
  • v ets erythroblastosis virus E26 oncogene like isoform 2 antibody
  • v-ets erythroblastosis virus E26 oncogene antibody
  • v-ets erythroblastosis virus E26 oncogene homolog (avian) antibody
  • V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e antibody
see all

Anti-ERG antibody images:

  Western blot - ERG antibody (ab87105)

Western blot - ERG antibody (ab87105)

Anti-ERG antibody (ab87105) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal liver lysate at 10 µg

Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution

Predicted band size : 52 kDa
Observed band size : 62 kDa (why is the actual band size different from the predicted?)
Additional bands at : 37 kDa. We are unsure as to the identity of these extra bands.

Gel concentration: 12%

References for Anti-ERG antibody (ab87105)

ab87105 has not yet been referenced specifically in any publications.

Publishing research using ab87105? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"