Anti-ERK1 antibody [EP4967] (ab109282)

Overview

• Product nameAnti-ERK1 antibody [EP4967]See all ERK1 primary antibodies ...
• Description
  Rabbit monoclonal [EP4967] to ERK1
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide corresponding to a region within Human ERK1

• Positive controlJurkat, A375, A431 and HUVEC cell lysates. Human colon adenocarcinoma tissue.
• General notesProduced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• Clonality Monoclonal
• Clone numberEP4967
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Signaling Pathways
  • TGF beta
  • Cytoplasmic

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Tangles & Tau

Applications

Target

• FunctionInvolved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
• Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
  Contains 1 protein kinase domain.
• DomainThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
• Post-translational
  modificationsDually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-204.

Target information above from: UniProt accession P27361 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5595 Human
  • Entrez Gene: 26417 Mouse
  • Entrez Gene: 50689 Rat
  • Omim: 601795 Human
  • SwissProt: P27361 Human
  • SwissProt: Q63844 Mouse
  • SwissProt: P21708 Rat
  • Unigene: 861 Human

  • Unigene: 8385 Mouse
  • Unigene: 2592 Rat

  see all

• Alternative names
  ERK 1 antibodyERK antibodyERK-1 antibody

  ERK1 antibodyERT 2 antibodyERT2 antibodyExtracellular Signal Regulated Kinase 1 antibodyExtracellular signal related kinase 1 antibodyExtracellular signal-regulated kinase 1 antibodyHGNC6877 antibodyHS44KDAP antibodyHUMKER1A antibodyInsulin Stimulated MAP2 Kinase antibodyInsulin-stimulated MAP2 kinase antibodyMAP kinase 1 antibodyMAP kinase 3 antibodyMAP Kinase antibodyMAP kinase isoform p44 antibodyMAPK 1 antibodyMAPK 3 antibodyMAPK antibodyMAPK1 antibodyMapk3 antibodyMGC20180 antibodyMicrotubule Associated Protein 2 Kinase antibodyMicrotubule-associated protein 2 kinase antibodyMitogen Activated Protein Kinase 3 antibodyMitogen-activated protein kinase 1 antibodyMitogen-activated protein kinase 3 antibodyMK03_HUMAN antibodyOTTHUMP00000174538 antibodyOTTHUMP00000174541 antibodyp44 ERK1 antibodyp44 MAPK antibodyp44-ERK1 antibodyp44-MAPK antibodyP44ERK1 antibodyP44MAPK antibodyPRKM 3 antibodyPRKM3 antibodyProtein Kinase Mitogen Activated 3 antibody

  see all

Anti-ERK1 antibody [EP4967] images

• 

  Western blot - ERK1 antibody [EP4967] (ab109282)
  All lanes : Anti-ERK1 antibody [EP4967] (ab109282) at 1/1000 dilution
  
  Lane 1 : Jurkat cell lysate
  Lane 2 : A375 cell lysate
  Lane 3 : A431 cell lysate
  Lane 4 : HUVEC cell lysate
  
  Lysates/proteins at 10 µg per lane.
  
  
  Predicted band size : 44 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ERK1 antibody [EP4967] (ab109282)
  Immunohistochemical analysis of paraffin-embedded Human colonic adenocarcinoma tissue using ab109282 at 1/100 dilution.