Anti-EYA2 antibody (ab54713)

Overview

• Product nameAnti-EYA2 antibodySee all EYA2 primary antibodies ...
• Description
  Mouse monoclonal to EYA2
• Tested applicationsWB, ICC/IF more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment, corresponding to amino acids 164-272 of Human EYA2

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Heterotrimeric G Proteins
  • G Proteins

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Co-factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Neuroscience
  • Sensory System
  • Visual system

Applications

Target

• FunctionTyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
• Tissue specificityHighest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
• Sequence similaritiesBelongs to the HAD-like hydrolase superfamily. EYA family.
• Developmental stageAt the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
• Cellular localizationCytoplasm. Nucleus.

Target information above from: UniProt accession O00167 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2139 Human
  • Omim: 601654 Human
  • SwissProt: O00167 Human
  • Unigene: 472877 Human
  • Unigene: 722040 Human
  • Unigene: 722415 Human
  • Unigene: 722416 Human

• Alternative names
  EAB 1 antibodyEAB1 antibodyEYA 2 antibody

  EYA2 antibodyEYA2_HUMAN antibodyeyes absent 2 homolog (Drosophila) antibodyEyes absent homolog 2 (Drosophila) antibodyEyes absent homolog 2 antibodyTranslation of this uORF probably lowers the translation efficiency of EYA2 antibody

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Anti-EYA2 antibody images

• 

  Western blot - Anti-EYA2 antibody (ab54713)
  
  
  Predicted band size : 59 kDa
  
• 

  Immunocytochemistry/ Immunofluorescence - EYA2 antibody (ab54713)

  ab54713 at 10 µg/ml staining EYA2 in human Hela cells by Immunocytochemistry / Immunofluorescence.