Edaravone (MCI-186), antioxidant (ab120645)
Key features and details
- Free radical scavenger with neuroprotective effects
- CAS Number: 89-25-8
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Edaravone (MCI-186), antioxidant -
Description
Free radical scavenger with neuroprotective effects -
Alternative names
- MCI-186
-
Biological description
Free radical scavenger and potent antioxidant. Inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system.
-
Purity
> 99% -
CAS Number
89-25-8 -
Chemical structure
Properties
-
Chemical name
3-Methyl-1-phenyl-2-pyrazolin-5-one -
Molecular weight
174.20 -
Molecular formula
C10H10N2O -
PubChem identifier
4021 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC1=NN(C(=O)C1)C2=CC=CC=C2 -
Source
Synthetic
-
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120645 has been referenced in 3 publications.
- Oh SJ et al. Ultrasonic Neuromodulation via Astrocytic TRPA1. Curr Biol 29:3386-3401.e8 (2019). PubMed: 31588000
- Cao A et al. Ursodeoxycholic Acid Ameliorated Diabetic Nephropathy by Attenuating Hyperglycemia-Mediated Oxidative Stress. Biol Pharm Bull 39:1300-8 (2016). PubMed: 27193377
- Jami MS et al. Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress. Neurochem Int 90:134-41 (2015). PubMed: 26232623