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- Secondary antibodies
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Product name
Anti-Endostatin antibody
See all Endostatin products (14) ...
Description
Goat polyclonal to Endostatin
Tested applications
WB, ELISA, IHC-Frmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Recombinant full length protein (Mouse) expressed in insect cell line Sf21.
Positive control
Tested with frozen sections of mouse brain.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 5% Trehalose, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic inhibitory factors
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Proteins >> Collagen
Cardiovascular >> Angiogenesis >> Inhibitors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11525 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.1 - 0.2 µg/ml. Detects a band of approximately 20-22 kDa.
ELISA: Use a concentration of 0.5 - 1 µg/ml.
IHC-Fr: Use a concentration of 15 µg/ml.
Target
Function
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Tissue specificity
Present in multiple organs with highest levels in liver, lung and kidney.
Involvement in disease
Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
Sequence similarities
Belongs to the multiplexin collagen family.
Contains 1 FZ (frizzled) domain.
Contains 1 TSP N-terminal (TSPN) domain.
Post-translational
modifications
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Cellular localization
Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accessionP39060
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Alpha 1 Collagen type 18 (XVIII)(COL18A1) antibody
- Alpha 1 type XVIII collagen antibody
- Antiangiogenic agent antibody
see all
Database links
- Entrez Gene: 12819 Mouse
- Entrez Gene: 12822 Mouse
- SwissProt: O35206 Mouse
- SwissProt: P39061 Mouse
- Unigene: 233547 Mouse
- Unigene: 4352 Mouse
References for Anti-Endostatin antibody (ab11525)
ab11525 has not yet been referenced specifically in any publications.
Publishing research using ab11525? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"