![- Anti-Endothelin 1 antibody [TR.ET.48.5] (ab2786) image](#ab2786_1.jpg)
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Product name
Anti-Endothelin 1 antibody [TR.ET.48.5]
See all Endothelin 1 products (10) ...
Description
Mouse monoclonal [TR.ET.48.5] to Endothelin 1
Specificity
Immunohistochemical staining of ET-1 in human corpus cavernosum tissue with this antibody results in staining of endothelial cells. Radioimmune assays can be used to concentrate ET-1 in solution (e.g. serum/plasma, milk, urine).
Tested applications
RIA, IHC-Fr, IHC-Pmore details
Cross reactivity
Reacts with
Rat, Human
Immunogen
Full length native protein (purified) conjugated to KLH.
Epitope
Studies suggest that this antibody binds to an epitope in the region of ET-1 represented by amino acids 8-16.
Positive control
human bowel
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
TR.ET.48.5
Isotype
IgG1
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolism processes >> Hypoxia
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Vasculature >> Vasoconstriction >> Other
Cardiovascular >> Vasculature >> Endothelium
Signal Transduction >> Growth Factors/Hormones >> Hormones
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- Anti-Endothelin 1 antibody [TR.ET.48.5] (ab2786)
![- Anti-Endothelin 1 antibody [TR.ET.48.5] (ab2786) image](/ps/datasheet/Images/2/ab2786/ab2786_1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab2786 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
RIA
RIA: 1/25000.RIA: 1/25000.
IHC-Fr
IHC-Fr: 1/250.IHC-Fr: 1/250.
IHC-P
IHC-P: 1/250.IHC-P: 1/250.
Target
Function
Endothelins are endothelium-derived vasoconstrictor peptides.
Tissue specificity
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.
Sequence similarities
Belongs to the endothelin/sarafotoxin family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP05305
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Big endothelin 1 antibody
- Big endothelin-1 antibody
- EDN 1 antibody
see all
Database links
- Entrez Gene: 1906 Human
- Entrez Gene: 24323 Rat
- Omim: 131240 Human
- SwissProt: P05305 Human
- SwissProt: P22388 Rat
- Unigene: 511899 Human
- Unigene: 713645 Human
- Unigene: 10918 Rat
Anti-Endothelin 1 antibody [TR.ET.48.5] images:
- Anti-Endothelin 1 antibody [TR.ET.48.5] (ab2786)
Figure 1 and Figure 2 show immunolocalization of ET-1 in human bowel using ab2786.
References for Anti-Endothelin 1 antibody [TR.ET.48.5] (ab2786)
This product has been referenced in:
- Mayyas F et al. Dietary ?3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model. Cardiovasc Res 89:852-61 (2011). Dog.Read more (PubMed: 21123218) »
- Liu Y et al. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res 9:1668-85 (2011).Read more (PubMed: 22013079) »
See all 7 publications for this product
Publishing research using ab2786? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"