EpCAM peptide (ab71914)
- 17 1A323/A3Adenocarcinoma associated antigen
- Adenocarcinoma-associated antigenAntigen identified by monoclonal antibody AUA1CD326CD326 antigenCell surface glycoprotein Trop 1Cell surface glycoprotein Trop-1CO 17ACO17 1ACO17ADIAR5EGPEGP 2EGP2EGP314EGP40Ep CAMEp-CAMEPCAMEPCAM_HUMANEpithelial cell adhesion moleculeEpithelial cell surface antigenEpithelial cellular adhesion moleculeEpithelial glycoproteinEpithelial glycoprotein 314ESAGA733 2GA733-2hEGP 2hEGP314HNPCC8Human epithelial glycoprotein 2KS 1/4 antigenKS1/4KSALymphocyte antigen 74M1S2M4S1Major gastrointestinal tumor associated protein GA733 2Major gastrointestinal tumor-associated protein GA733-2Membrane component chromosome 4 surface marker (35kD glycoprotein)MIC18MK 1TACD1TACSTD1TROP1Tumor associated calcium signal transducer 1Tumor-associated calcium signal transducer 1
Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) [MIM:613244]. HNPCC is a disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Note=HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.
Contains 1 thyroglobulin type-1 domain.
modificationsHyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
References for EpCAM peptide (ab71914)
ab71914 has not yet been referenced specifically in any publications.