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Overview

  • Product nameEpCAM peptideSee all EpCAM proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 100 - 200 of Human EpCAM.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab68892 - .
  • Protein length18 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab168828 and ab168849.

    • Protein info

    • Alternative names
        17 1A323/A3Adenocarcinoma associated antigen
        Adenocarcinoma-associated antigenAntigen identified by monoclonal antibody AUA1CD326CD326 antigenCell surface glycoprotein Trop 1Cell surface glycoprotein Trop-1CO 17ACO17 1ACO17ADIAR5EGPEGP 2EGP2EGP314EGP40Ep CAMEp-CAMEPCAMEPCAM_HUMANEpithelial cell adhesion moleculeEpithelial cell surface antigenEpithelial cellular adhesion moleculeEpithelial glycoproteinEpithelial glycoprotein 314ESAGA733 2GA733-2hEGP 2hEGP314HNPCC8Human epithelial glycoprotein 2KS 1/4 antigenKS1/4KSALymphocyte antigen 74M1S2M4S1Major gastrointestinal tumor associated protein GA733 2Major gastrointestinal tumor-associated protein GA733-2Membrane component chromosome 4 surface marker (35kD glycoprotein)MIC18MK 1TACD1TACSTD1TROP1Tumor associated calcium signal transducer 1Tumor-associated calcium signal transducer 1
      see all
  • FunctionMay act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
  • Tissue specificityHighly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
  • Involvement in diseaseDefects in EPCAM are the cause of diarrhea type 5 (DIAR5) [MIM:613217]. It is an intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.
    Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) [MIM:613244]. HNPCC is a disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Note=HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.
  • Sequence similaritiesBelongs to the EPCAM family.
    Contains 1 thyroglobulin type-1 domain.
  • Post-translational
    modifications    Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
  • Cellular localizationLateral cell membrane. Cell junction > tight junction. Co-localizes with CLDN7 at the lateral cell membrane and tight junction.

    • Target information above from: UniProt accession P16422 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for EpCAM peptide (ab71914)

    ab71914 has not yet been referenced specifically in any publications.

    Publishing research using ab71914 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab71914 Submit a Question for ab71914

    Displaying 1 - 6 of 6 results for Abreviews and Q&A

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    Does this peptide have any modifications (tags or glycosylations)?

    Thank you very much for your call yesterday and for your questions about this peptide.
    I have confirmed with the lab that this peptide does not have any modifications. It was tested by mass spectrometry and the HPLC purity is greater than 90%.
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    Good afternoon!
    May i ask you a question about your peptide product with cat N0. ab71914?

    we bought it for experiment, and got to know that the peptide is of 18aa in length, with PI value of 9.52. is that right? expe

    But my expe...

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    Thank you for your inquiry.

    This peptide is 18 a.a. long. The note on the website is for the protein length, meaning that the full length protein is 314 a.a. long,from which the 18 a.a. peptide is derived.

    We have not determined the PI...

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    May i ask about the HPLC detect method for EPCAM ab71914? Thank you very much!

    Thank you for contacting Abcam regarding ab71914.


    Attached please find the HPLC data you requested.


    I hope this information is helpful. Please do not hesitate to contact us if you have any additoinal questions.

    Good afternoon!

    Can i ask about the active buffer for EpCAMab71914 peptide?

    Thank you for contacting Abcam.

    The storage buffer for ab71914 is TK buffer (30mM HEPES,150mM NaCl, 2mM EDTA, 0.001% Tween-20, pH 6.75).

    If there is anything else I can help you with, please let me know.

    .

    Will this antibody be affected by endocytosis?

    Thank you for contacting Abcam regarding ab71914.


    I have confirmed with the lab that unfortunately,we don't know if this antibody would survive or affect endocytosis. We've never tested this product in any functional studies and therefore ...

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    Dear Sir/Madam

    Good morning!

    I am writing from Univerisity of Kentucky,

    I would like to buy EpCAM peptide from extracellular domain for one project, i noticed that from your website there two kinds of human resourced EpCAM...

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    Thank you for your inquiry.

    These two peptide are only 20 amino acids long each. They are not comprised of the whole protein or even parts of the protein.

    They are short peptides used fro immunization in antibody production and are onl...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"