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Overview

  • Product nameEph receptor A3 protein (Active)See all Eph receptor A3 proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 571-983 of Human Eph receptor A3 with N-terminal proprietary tag, expressed in a Baculovirus infected Sf9 cell expression system, 72kDa. Swiss ID = P29320.
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesPurity was determined to be >90% by densitometry.
  • Biological activitySpecific activity of Eph receptor A3 was determined to be 102 nmol/min/mg as per activity assay protocol.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84576 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Functional Studies
    SDS-PAGE
  • Application notesFuncS: Kinae activity. Use at an assay dependent dilution.
    SDS-PAGE: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 110 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        AW492086Cek4EC 2.7.10.1
        EK4End3Eph receptor A3EPH-like kinase 4EPH-like tyrosine kinase 1EphA3EPHA3_HUMANEphrin receptor EphA3Ephrin type-A receptor 3ETKETK 1ETK1HEKHEK 4HEK4Human embryo kinaseMek4MGC109882Receptor tyrosine kinase HEKTyro 4Tyro4Tyrosine protein kinase receptor ETK 1Tyrosine-protein kinase receptor ETK1Tyrosine-protein kinase TYRO4
      see all
  • FunctionReceptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
  • Tissue specificityWidely expressed. Highest level in placenta.
  • Involvement in diseaseDefects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P29320 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Eph receptor A3 protein (Active) images

    • Functional Studies - Eph receptor A3 protein (Active) (ab84576)
      Functional Studies - Eph receptor A3 protein (Active) (ab84576)
      Specific activity of Eph receptor A3 was determined to be 102 nmol/min/mg as per activity assay protocol.
    • SDS-PAGE - Eph receptor A3 protein (Active) (ab84576)
      SDS-PAGE - Eph receptor A3 protein (Active) (ab84576)
      Purity of Eph receptor A3 was determined to be >90% by densitometry, approx. MW 72kDa.

    References for Eph receptor A3 protein (Active) (ab84576)

    ab84576 has not yet been referenced specifically in any publications.

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