Anti-Eph receptor B2 antibody (ab54650)
- Product nameAnti-Eph receptor B2 antibodySee all Eph receptor B2 primary antibodies ...
- DescriptionMouse monoclonal to Eph receptor B2
- Tested applicationsWB more details
- Species reactivityReacts with: Mouse, Human
Recombinant fragment: CIANAEEVDV PIKLYCNGDG EWLVPIGRCM CKAGFEAVEN GTVCRGCPSG TFKANQGDEA CTHCPINSRT TSEGATNCVC RNGYYRADLD PLDMPCTTIP , corresponding to amino acids 226-325 of Human Eph receptor B2
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
PBS, pH 7.2
- Concentration information loading...
- PurityProtein G purified
- Clonality Monoclonal
- Light chain typekappa
Our Abpromise guarantee covers the use of ab54650 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionReceptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.
- Tissue specificityBrain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
- Involvement in diseaseDefects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
- Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
- Cellular localizationMembrane.
- cek5 antibodyDevelopmentally regulated EPH related tyrosine kinase antibodyDRT antibody
- EK5 antibodyELK related protein tyrosine kinase antibodyEph receptor B2 antibodyEPH tyrosine kinase 3 antibodyEPH-like kinase 5 antibodyEphB2 antibodyEPHB2_HUMAN antibodyEphrin type B receptor 2 antibodyEphrin type-B receptor 2 antibodyEPHT 3 antibodyERK antibodyETECK antibodyhEK5 antibodyNuk antibodyPrkm 5 antibodyReceptor protein tyrosine kinase HEK 5 antibodyRenal carcinoma antigen NY-REN-47 antibodySek 3 antibodyTyro 5 antibodyTyrosine protein kinase receptor CEK 5 antibodyTyrosine protein kinase receptor EPH 3 antibodyTyrosine protein kinase receptor QEK 5 antibodyTyrosine-protein kinase receptor EPH-3 antibodyTyrosine-protein kinase TYRO5 antibody
Anti-Eph receptor B2 antibody images
Predicted band size : 118 kDa
Eph receptor B2 antibody (ab54650) at 1ug/lane + NIH/3T3 cell lysate at 25ug/lane.
References for Anti-Eph receptor B2 antibody (ab54650)
ab54650 has not yet been referenced specifically in any publications.