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Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - c-ErbB2 antibody (ab27086)
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Product Name
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ErbB 2 antibody
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See all ErbB 2 antibodies (39)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to ErbB 2
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Immunogen
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Synthetic peptide coresponding to amino acids from the C terminus of human c-ErbB2.
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Mk, Rb
(Due to sequence homology)
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Tested applications
(see key)
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IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/300 for 10 min at room temperature. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.
Staining pattern: Cell membrane.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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SKBR3 cells or human breast carcinoma for Immunohistochemistry.
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Cellular localization
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Cell Membrane; single pass type I membrane protein
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Research areas
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Cancer >> Tumor biomarkers >> Oncoproteins
Cancer >> Tumor immunology >> Tumor-associated antigens
Cancer >> Growth factors >> EGF
Signal Transduction >> Growth Factors/Hormones >> EGF
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
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Relevance
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ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ErbB 2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for ErbB 2 antibody images, references, products related to ab27086 and other tools.
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ErbB 2 antibody images:
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 Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - c-ErbB2 antibody (ab27086)
Ab27086, at a dilution of 1/300, staining c-ErbB2 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry.
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Search PubMed (MEDLINE) for references to ErbB 2
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ErbB 2 antibody - more information
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Customer reviews (feedback) regarding ErbB 2 antibody |
Customer FAQs regarding ErbB 2 antibody |
Protocols for ErbB 2 antibody |
Price and availability of products related to ErbB 2 antibody |
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ErbB 2 antibody - related products:
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ErbB 2 antibody - other tools:
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Contact Abcam with a Technical Enquiry about ErbB 2 antibody |
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