Overview
Product nameErbB 3 protein (Tagged)See all ErbB 3 proteins and peptides ...
Protein descriptionRecombinant fragment of human ErbB3 (extracellular domain) corresponding to amino acids 1-190 of Human ErbB 3. A single, non-glycosylated, fusion polypeptide chain containing a Thyrodoxin Tag and a His tag. Total M.Wt 34 kDa. SwissProt P21860.
Expression hostE. coli
Properties
Purity> 95
% by SDS-PAGE
Purification notesab73634 is purified by proprietary chromatographic techniques.
Purity:Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
FormLiquid
Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: aluminum hydroxide, arginine, sodium chloride, sodium phosphate buffer and potassium phosphate.
Concentration information loading...
Additional notesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
ab73634 is supplied as a white semitransparent suspension.
Sequence notesMRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG RSCPPCHEVC
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab73634
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|
Application
|
Notes |
| SDS-PAGE |
|
| Functional Studies |
|
Application notesBiological Activity:Measured by its ability to postpone the tumor emergence time of spontaneous breast cancers in FVB/N transgenic mice and to inhibit the development of tumors. ab 73634 can also effectively inhibit the growth of in situ transplanted breast tumours in FVB/N transgenic mice.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
-
Alternative names
ERBB3 proteinerbB3 SERBB3_HUMANGlial growth factor receptorHER 3HER3LCCS2MDA BF 1MGC88033p180 ErbB3p45 sErbB3p85 sErbB3proto-oncogene-like protein c ErbB 3proto-oncogene-like protein c ErbB3Proto-oncogene-like protein c-ErbB-3Receptor tyrosine protein kinase erbB 3Receptor tyrosine protein kinase erbB3Receptor tyrosine-protein kinase erbB-3Tyrosine kinase type cell surface receptor HER3Tyrosine kinase-type cell surface receptor HER3v erb b2 avian erythroblastic leukemia viral oncogene homolog 3v erb b2 erythroblastic leukemia viral oncogene homolog 3v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
see all
FunctionBinds and is activated by neuregulins and NTAK.
Tissue specificityEpithelial tissues and brain.
Involvement in diseaseDefects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Contains 1 protein kinase domain.
Developmental stageOverexpressed in a subset of human mammary tumors.
DomainThe cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
Post-translational
modificationsLigand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
Cellular localizationSecreted and Cell membrane.
References for ErbB 3 protein (Tagged) (ab73634)
ab73634
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
