Overview

  • Product name
    Erbstatin Analog
  • Description
    EGFR tyrosine kinase inhibitor
  • Alternative names
    • 2,5-Dihydroxycinnamic Acid Methyl Ester
    • 2,5-MeC
    • Methyl 2,5-dihydroxycinnamate
  • Biological description

    Stable inhibitor of EGF receptor-associated tyrosine in vitro ((IC50 = 0.15 µg/ml). Inhibition is competitive with substrate and noncompetitive with ATP. Approximately 4 times more stable than Erbstatin in calf serum. Shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of DNA synthesis.

  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Komura N  et al. Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells. Exp Cell Res 313:2753-65 (2007). Read more (PubMed: 17585903) »
  • Koch JA  et al. Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells. Biochem Biophys Res Commun 225:531-6 (1996). Read more (PubMed: 8753796) »
  • Kawada M  et al. Inhibition of Abelson oncogene function by erbstatin analogues. Drugs Exp Clin Res 19:235-41 (1993). Read more (PubMed: 8013266) »
  • Azuma Y  et al. Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins. Cell Immunol 152:271-8 (1993). Read more (PubMed: 8242767) »
  • Umezawa K  et al. Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells. FEBS Lett 314:289-92 (1992). Read more (PubMed: 1468560) »
  • Umezawa K  et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett 260:198-200 (1990). Read more (PubMed: 2298299) »

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