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Product name
Esomeprazole sodium
Description
H+/ K+-ATPase (proton pump) inhibitor
Biological description
H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). S-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19, CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM respectively).
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt
Molecular Weight
367.40
Chemical structure
Molecular formula
C17H18N3NaO3S
CAS Number
161796-78-7
Solubility
Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Receptors & Transporters >> Transporters >> Ion pumps / transporter >> H+/K+ ATPase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for Esomeprazole sodium (ab120500)
This product has been referenced in:
- Fornai M et al. Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms. Pharmacol Res 63:59-67 (2011).Read more (PubMed: 20969958) »
- Kodama K et al. E3710, a new proton pump inhibitor, with a long-lasting inhibitory effect on gastric acid secretion. J Pharmacol Exp Ther 334:395-401 (2010).Read more (PubMed: 20484556) »
See all 3 publications for this product
Publishing research using ab120500? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"