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Products:Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
Overview
Product name
Anti-FAIM2 antibody
See all FAIM2 products (3) ...
Description
Rabbit polyclonal to FAIM2
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
16 amino acid peptide from near the amino terminus of human FAIM2.
Positive control
EL4 cells lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Caspases
Immunology >> Innate Immunity >> Cytokines >> TNF Superfamily
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Cell Biology >> Apoptosis >> Receptors >> Death Receptors
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
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Western blot - FAIM2 antibody (ab58912)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58912 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Detects a band of approximately 33 kDa (predicted molecular weight: 38 kDa).
Target
Relevance
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Cellular localization
Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).
Alternative names
- FAIM 2 antibody
- FAIM2 antibody
- Fas apoptotic inhibitory molecule 2 antibody
see all
Database links
- Entrez Gene: 23017 Human
- Entrez Gene: 72393 Mouse
- Entrez Gene: 246274 Rat
- Omim: 604306 Human
- SwissProt: Q9BWQ8 Human
- SwissProt: Q8K097 Mouse
- SwissProt: O88407 Rat
- Unigene: 567424 Human
see all
Anti-FAIM2 antibody images:
Western blot - FAIM2 antibody (ab58912)
Lane 1 : Anti-FAIM2 antibody (ab58912) at 0.5 µg/ml
Lane 2 : Anti-FAIM2 antibody (ab58912) at 1 µg/ml
Lane 1 : EL4 cell lysate
Lane 2 : EL4 cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 38 kDa
Observed band size : 33 kDa (why is the actual band size different from the predicted?)
References for Anti-FAIM2 antibody (ab58912)
ab58912 has not yet been referenced specifically in any publications.
Publishing research using ab58912? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"