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Products:Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
Overview
Product name
Anti-FAIM2 antibody
See all FAIM2 products (3) ...
Description
Rabbit polyclonal to FAIM2
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide (Human): 16 amino acid peptide from near the amino terminus of human FAIM2.
Positive control
Human brain, cortex tissue.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FAIM2 antibody (ab64187)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab64187 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.
IHC-P: Use a concentration of 5 µg/ml
Target
Relevance
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Cellular localization
Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).
Alternative names
- FAIM 2 antibody
- Fas apoptotic inhibitory molecule 2 antibody
- KIAA0950 antibody
see all
Database links
- Entrez Gene: 23017 Human
- Entrez Gene: 72393 Mouse
- Entrez Gene: 246274 Rat
- Omim: 604306 Human
- SwissProt: Q9BWQ8 Human
- SwissProt: Q8K097 Mouse
- SwissProt: O88407 Rat
- Unigene: 567424 Human
see all
Anti-FAIM2 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FAIM2 antibody (ab64187)
Ab64187 (5ug/ml) staining human FAIM2 in human brain, cortex tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.
References for Anti-FAIM2 antibody (ab64187)
ab64187 has not yet been referenced specifically in any publications.
Publishing research using ab64187? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"