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Products:Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
Overview
Product name
Anti-FAIM2 antibody
See all FAIM2 products (3) ...
Description
Rabbit polyclonal to FAIM2
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Dog, Human, Monkey
Predicted to work with
Chicken, Opossum
Immunogen
A portion of amino acids 1-50 of human FAIM2 isoform A.
Positive control
Human, mouse and rat brain lysates. Human cerebellum tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 0.2% Gelatin, PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72113 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 3 µg/ml.Detects a band of approximately 29 kDa (predicted molecular weight: 35 kDa).
IHC-P: Use a concentration of 10 µg/ml
Target
Relevance
Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Cellular localization
Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).
Alternative names
- FAIM 2 antibody
- Fas apoptotic inhibitory molecule 2 antibody
- LFG antibody
see all
Database links
- Entrez Gene: 23017 Human
- Entrez Gene: 72393 Mouse
- Entrez Gene: 246274 Rat
- Omim: 604306 Human
- SwissProt: Q9BWQ8 Human
- SwissProt: Q8K097 Mouse
- SwissProt: O88407 Rat
- Unigene: 567424 Human
see all
Anti-FAIM2 antibody images:
Western blot - FAIM2 antibody (ab72113)
Lanes 1 - 2 : Anti-FAIM2 antibody (ab72113) at 2 µg/ml
Lane 3 : Anti-FAIM2 antibody (ab72113) at 1 µg/ml
Lane 4 : Anti-FAIM2 antibody (ab72113) at 0.5 µg/ml
Lane 1 : human brain lysate
Lane 2 : human brain lysate with immunizing peptide
Lane 3 : mouse brain lysate
Lane 4 : rat brain lysate
Predicted band size : 35 kDa
Observed band size : 29 kDa (why is the actual band size different from the predicted?)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FAIM2 antibody (ab72113)
Analysis of FAIM2 expression in human cerebellum tissue, using ab72113 at 10 ug/ml.
References for Anti-FAIM2 antibody (ab72113)
ab72113 has not yet been referenced specifically in any publications.
Publishing research using ab72113? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"