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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
Overview
Product name
Anti-FANCA antibody
See all FANCA products (5) ...
Description
Rabbit polyclonal to FANCA
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide designed within residues 1200-1300 of Human FANCA
Positive control
FANCA-transfected COS1 cell lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
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Western blot - FANCA antibody (ab81632)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab81632 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Predicted molecular weight: 163 kDa.
Target
Function
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Involvement in disease
Defects in FANCA are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.
Cellular localization
Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Target information above from: UniProt accessionO15360
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- FA 1 antibody
- FA antibody
- FA H antibody
see all
Database links
- Entrez Gene: 2175 Human
- Omim: 607139 Human
- SwissProt: O15360 Human
- Unigene: 290154 Human
Anti-FANCA antibody images:
Western blot - FANCA antibody (ab81632)
Anti-FANCA antibody (ab81632) at 1/1000 dilution + transfected COS1 cell lysate
Predicted band size : 163 kDa
Observed band size : 163 kDa
References for Anti-FANCA antibody (ab81632)
ab81632 has not yet been referenced specifically in any publications.
Publishing research using ab81632? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"