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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
Overview
Product name
Anti-FANCF antibody
See all FANCF products (2) ...
Description
Rabbit polyclonal to FANCF
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human FANCF.
(Peptide available as ab49619.)
Positive control
This antibody gave a positive signal in Human Brain Tissue Lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
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Western blot - FANCF antibody (ab47624)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab47624 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlDetects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
Target
Function
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Involvement in disease
Defects in FANCF are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ9NPI8
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- A730016A17 antibody
- FACF antibody
- FAF antibody
see all
Database links
- Entrez Gene: 2188 Human
- Omim: 603467 Human
- SwissProt: Q9NPI8 Human
- Unigene: 713574 Human
Anti-FANCF antibody images:
Western blot - FANCF antibody (ab47624)
Anti-FANCF antibody (ab47624) at 1 µg/ml + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µg
Secondary
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size : 42 kDa
Observed band size : 42 kDa
Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.
References for Anti-FANCF antibody (ab47624)
ab47624 has not yet been referenced specifically in any publications.
Publishing research using ab47624? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"