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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
Overview
Product name
Anti-FANCG antibody
See all FANCG products (6) ...
Description
Rabbit polyclonal to FANCG
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: MSRQTTSVGSSC, corresponding to amino acids 1 - 12 of Human FANCG.
MSRQTTSVGS SC
General notes
Avoid cycles of freezing and thawing.
Expiration date is one (1) year from date of opening.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
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Western blot - FANCG antibody (ab5067)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab5067 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).
Target
Function
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Tissue specificity
Highly expressed in testis and thymus. Found in lymphoblasts.
Involvement in disease
Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
Sequence similarities
Contains 4 TPR repeats.
Cellular localization
Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Target information above from: UniProt accessionO15287
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA repair protein XRCC9 antibody
- DNA-repair protein XRCC9 antibody
- FAG antibody
see all
Database links
- Entrez Gene: 2189 Human
- Omim: 602956 Human
- SwissProt: O15287 Human
- Unigene: 591084 Human
Anti-FANCG antibody images:
Western blot - FANCG antibody (ab5067)
Anti-FANCG antibody (ab5067) at 1/500 dilution + HeLa whole cell lysate at 35 µg
Secondary
IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution
Performed under reducing conditions.
Predicted band size : 69 kDa
Observed band size : 69 kDa
Additional bands at : 11 kDa,24 kDa. We are unsure as to the identity of these extra bands.
References for Anti-FANCG antibody (ab5067)
ab5067 has not yet been referenced specifically in any publications.
Publishing research using ab5067? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"