You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-FBXO31 antibodySee all FBXO31 primary antibodies ...
  • Description
    Rabbit polyclonal to FBXO31
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide, corresponding to a region within the amino acids 489-539 of Human FBXO31, NP_079011.3

  • Positive controlWhole cell lysate from 293T and mouse NIH3T3 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab86137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/1000 - 1/5000. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).
  • Application notesIs unsuitable for or IP.

    • Target

    • FunctionComponent of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
    • Tissue specificityHighly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesBelongs to the FBXO31 family.
      Contains 1 F-box domain.
    • Developmental stageExpression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level).
    • Post-translational
      modifications      Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.

      • Target information above from: UniProt accession Q5XUX0 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          DKFZp434B027 antibodyDKFZp434J1815 antibodyF box only protein 31 antibody
          F box protein 31 antibodyF-box only protein 31 antibodyFBX14 antibodyFBX31 antibodyFBX31_HUMAN antibodyFBXO14 antibodyFbxo31 antibodyFLJ22477 antibodyMGC15419 antibodyMGC9527 antibodypp2386 antibodyPutative breast cancer tumor suppressor antibodySCF ubiquitin ligase specificity factor antibody
        see all

      Anti-FBXO31 antibody images

      • Western blot - FBXO31 antibody (ab86137)
        Western blot - FBXO31 antibody (ab86137)
        All lanes : Anti-FBXO31 antibody (ab86137) at 0.4 µg/ml

        Lane 1 : Whole cell lysate from 293T cells
        Lane 2 : Whole cell lysate from mouse NIH3T3 cells

        Lysates/proteins at 50 µg per lane.


        Predicted band size : 61 kDa
        Observed band size : 61 kDa


        Exposure time : 30 seconds

      References for Anti-FBXO31 antibody (ab86137)

      ab86137 has not yet been referenced specifically in any publications.

      Publishing research using ab86137 ? Please let us know so that we can cite the reference in this datasheet

      Product Wall

      Submit an Abreview for ab86137 Submit a Question for ab86137

      There are currently no Abreviews or Questions for ab86137.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"