Overview

  • Product nameAnti-FCGR1A antibody [EPR4623]See all FCGR1A primary antibodies ...
  • Description
    Rabbit monoclonal [EPR4623] to FCGR1A
  • Tested applicationsWB, IP, Flow Cyt more details
  • Species reactivity
    Reacts with: Human

    Does not react with

    Mouse, Rat
  • Immunogen

    A synthetic peptide corresponding to residues in the extracellular domain of Human FCGR1A.

  • Positive control
    • U937, THP1, and HL60 cell lysates; U937 cells.
  • General notesProduced under U.S. Patent No. 5,675,063.

Properties

Applications

Our Abpromise guarantee covers the use of ab109449 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/1000 - 1/10000. Detects a band of approximately 64-78 kDa (predicted molecular weight: 43 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/100 - 1/500.
  • Application notesIs unsuitable for IHC-P.
  • Target

    • FunctionHigh affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
    • Tissue specificityMonocyte/macrophage specific.
    • Sequence similaritiesBelongs to the immunoglobulin superfamily. FCGR1 family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    • Post-translational
      modifications
      Phosphorylated on serine residues.
    • Cellular localizationCell membrane. Stabilized at the cell membrane through interaction with FCER1G.
    • Target information above from: UniProt accession P12314 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • CD64 antibody
      • CD64A antibody
      • Fc fragment of IgG high affinity Ia receptor (CD64) antibody
      • Fc fragment of IgG, high affinity Ia, receptor for antibody
      • Fc gamma receptor antibody
      • Fc gamma receptor I A1 antibody
      • Fc gamma RI antibody
      • Fc gamma RIA antibody
      • Fc-gamma RI antibody
      • Fc-gamma RIA antibody
      • FCG1 antibody
      • FcgammaRIa antibody
      • FCGR1 antibody
      • FCGR1_HUMAN antibody
      • FCGR1A antibody
      • FcRI antibody
      • FLJ18345 antibody
      • High affinity immunoglobulin gamma Fc receptor I antibody
      • IGFR1 antibody
      • IgG Fc receptor I antibody
      • Immunoglobulin G Fc receptor I antibody
      • OTTHUMP00000013913 antibody
      see all

    Anti-FCGR1A antibody [EPR4623] images

    • All lanes : Anti-FCGR1A antibody [EPR4623] (ab109449) at 1/1000 dilution

      Lane 1 : U937 cell lysate
      Lane 2 : THP1 cell lysate
      Lane 3 : HL60 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 43 kDa
      Observed band size : 64-78 kDa (why is the actual band size different from the predicted?)
    • ab109449 at 1/100 dilution staining FCGR1A in U937 cells by Flow cytometry (shown in red). Rabbit IgG negative control (shown in green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References for Anti-FCGR1A antibody [EPR4623] (ab109449)

    ab109449 has not yet been referenced specifically in any publications.

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