Anti-FCGR1A antibody [EPR4623] (ab109449)

Overview

• Product nameAnti-FCGR1A antibody [EPR4623]See all FCGR1A primary antibodies ...
• Description
  Rabbit monoclonal [EPR4623] to FCGR1A
• Tested applicationsWB, IP, Flow Cyt more details
• Species reactivity
  Reacts with: Human
  

  Does not react with

  Mouse, Rat
• Immunogen

  A synthetic peptide corresponding to residues in the extracellular domain of Human FCGR1A.

• Positive controlU937, THP1, and HL60 cell lysates; U937 cells.
• General notesProduced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Dissociation constant (Kd) Kd = 1.00 x 10^-11 M
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• Clonality Monoclonal
• Clone numberEPR4623
• IsotypeIgG
• Research Areas
  • Immunology
  • Innate Immunity
  • Fc Receptors

  • Immunology
  • Immunoglobulins
  • Heavy Chain
  • IgG

Applications

Target

• FunctionHigh affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
• Tissue specificityMonocyte/macrophage specific.
• Sequence similaritiesBelongs to the immunoglobulin superfamily. FCGR1 family.
  Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
• Post-translational
  modificationsPhosphorylated on serine residues.
• Cellular localizationCell membrane. Stabilized at the cell membrane through interaction with FCER1G.

Target information above from: UniProt accession P12314 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2209 Human
  • Omim: 146760 Human
  • SwissProt: P12314 Human
  • Unigene: 77424 Human

• Alternative names
  CD64 antibodyCD64A antibodyFc fragment of IgG high affinity Ia receptor (CD64) antibody

  Fc fragment of IgG, high affinity Ia, receptor for antibodyFc gamma receptor antibodyFc gamma receptor I A1 antibodyFc gamma RI antibodyFc gamma RIA antibodyFc-gamma RI antibodyFc-gamma RIA antibodyFCG1 antibodyFcgammaRIa antibodyFCGR1 antibodyFCGR1_HUMAN antibodyFCGR1A antibodyFcRI antibodyFLJ18345 antibodyHigh affinity immunoglobulin gamma Fc receptor I antibodyIGFR1 antibodyIgG Fc receptor I antibodyImmunoglobulin G Fc receptor I antibodyOTTHUMP00000013913 antibody

  see all

Anti-FCGR1A antibody [EPR4623] images

• 

  Western blot - FCGR1A antibody [EPR4623] (ab109449)
  All lanes : Anti-FCGR1A antibody [EPR4623] (ab109449) at 1/1000 dilution
  
  Lane 1 : U937 cell lysate
  Lane 2 : THP1 cell lysate
  Lane 3 : HL60 cell lysate
  
  Lysates/proteins at 10 µg per lane.
  
  
  Predicted band size : 43 kDa
  Observed band size : 64-78 kDa (why is the actual band size different from the predicted?)
  
• 

  Flow Cytometry - FCGR1A antibody [EPR4623] (ab109449)
  ab109449 at 1/100 dilution staining FCGR1A in U937 cells by Flow cytometry (shown in red). Rabbit IgG negative control (shown in green).
• 

  Other-Anti-FCGR1A antibody [EPR4623](ab109449)
  Equilibrium disassociation constant (K_D)
  Learn more about K_D
  
  Click here to learn more about K_D