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Anti-FCP1 antibody (ab54534)

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Overview

Product name

Anti-FCP1 antibody
See all FCP1 products (5) ...

Description

Rabbit polyclonal to FCP1

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Recombinant Fragment

Predicted to work with

Mouse, Human

Immunogen

Synthetic peptide corresponding to N terminal residues of mouse FCP1.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

ab54534 was purified by antigen specific affinity chromatography.

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab54534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 1 µg/mlPredicted molecular weight: 104 kDa.(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

Target

Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II.

Tissue specificity

Ubiquitously expressed. Isoform 3 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and placenta.

Involvement in disease

Defects in CTDP1 are a cause of congenital cataracts facial dysmorphism and neuropathy syndrome (CCFDN) [MIM:604168]. CCFDN is an autosomal recessive developmental disorder that occurs in an endogamous group of Vlax Roma (Gypsies). The syndrome is characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures).

Sequence similarities

Contains 1 BRCT domain.
Contains 1 FCP1 homology domain.

Post-translational
modifications

Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ9Y5B0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CCFDN antibody
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 antibody
  • CTD of POLR2A, phosphatase of, subunit 1 antibody
  • CTDP1 antibody
  • CTDP1_HUMAN antibody
  • EC 3.1.3.16 antibody
  • RNA polymerase II subunit A C terminal domain phosphatase antibody
  • RNA polymerase II subunit A C-terminal domain phosphatase antibody
  • Serine phosphatase FCP1a antibody
  • TFIIF associating CTD phosphatase antibody
  • TFIIF-associating CTD phosphatase 1 antibody
  • TFIIF-associating CTD phosphatase antibody
  • Transcription factor IIF-associating CTD phosphatase 1 antibody
see all

References for Anti-FCP1 antibody (ab54534)

ab54534 has not yet been referenced specifically in any publications.

Publishing research using ab54534? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"