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Anti-FGF basic antibody [MC-GF1] (ab181)

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Overview

Product name

Anti-FGF basic antibody [MC-GF1]
See all FGF basic products (27) ...

Description

Mouse monoclonal [MC-GF1] to FGF basic

Specificity

GF1 recognises basic fibroblast growth factor (bFGF). The antibody binds strongly to bFGF attached to proteoglycans, but is competitively displaced by heparin.

Tested applications

ELISA, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Human, Pig

Immunogen

Recombinant full length protein (Human).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.1% sodium azide

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Clonality

Monoclonal

Clone number

MC-GF1

Myeloma

Sp2

Isotype

IgG2a

Light chain type

unknown

Research areas

Developmental Biology >> Organogenesis >> Excretory system development >> Kidney development
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> FGF
Stem Cells >> Neural Stem Cells >> Extracellular
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> FGF
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF

Applications

Show applications key

Our Abpromise guarantee covers the use of ab181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Tissue specificity

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Post-translational
modifications

Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Cellular localization

Secreted. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane.

Target information above from: UniProt accessionP09038 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Basic fibroblast growth factor antibody
  • BFGF antibody
  • FGF 2 antibody
  • FGF B antibody
  • FGF-2 antibody
  • FGF2 antibody
  • FGF2 basic antibody
  • FGF2_HUMAN antibody
  • FGFB antibody
  • Fibroblast growth factor 2 (basic) antibody
  • Fibroblast growth factor 2 antibody
  • HBGF 2 antibody
  • HBGF-2 antibody
  • HBGF2 antibody
  • HBGH 2 antibody
  • HBGH2 antibody
  • Heparin binding growth factor 2 precursor antibody
  • Heparin-binding growth factor 2 antibody
  • Prostatropin antibody
see all

Database links

References for Anti-FGF basic antibody [MC-GF1] (ab181)

This product has been referenced in:

  • He W  et al. Blockade of Wnt/ß-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22:90-103 (2011). WB; Mouse.Read more (PubMed: 21030600) »
  • Wang D  et al. PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression. PLoS One 6:e17048 (2011). WB; Human.Read more (PubMed: 21390327) »

See all 5 publications for this product

Publishing research using ab181? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"