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- Secondary antibodies
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Product name
Anti-FGF basic antibody
See all FGF basic products (27) ...
Description
Rabbit polyclonal to FGF basic
Specificity
This antibody recognises FGF basic (FGF2).
Tested applications
WB, IHC-P, Dot Blotmore details
Cross reactivity
Reacts with
Rat
Predicted to work with
Mouse, Human
Immunogen
Synthetic peptide, corresponding to amino acids 1-24 of Rat FGF basic.
MAAGSITSLPALPEDGGGAFPPGH
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Liquid antiserum
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Organogenesis >> Excretory system development >> Kidney development
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> FGF
Stem Cells >> Neural Stem Cells >> Extracellular
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> FGF
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8881 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution.
IHC-P
IHC-P: 1/2000 - 1/8000.IHC-P: 1/2000 - 1/8000.
Dot: Use at an assay dependent dilution.
Target
Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Tissue specificity
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Sequence similarities
Belongs to the heparin-binding growth factors family.
Post-translational
modifications
Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
Cellular localization
Secreted. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane.
Target information above from: UniProt accessionP09038
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Basic fibroblast growth factor antibody
- BFGF antibody
- FGF 2 antibody
see all
Database links
- Entrez Gene: 2247 Human
- Entrez Gene: 14173 Mouse
- Entrez Gene: 54250 Rat
- Omim: 134920 Human
- SwissProt: P09038 Human
- SwissProt: P15655 Mouse
- SwissProt: P13109 Rat
- Unigene: 284244 Human
see all
References for Anti-FGF basic antibody (ab8881)
ab8881 has not yet been referenced specifically in any publications.
Publishing research using ab8881? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"