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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab8881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution.
IHC-P IHC-P: 1/2000 - 1/8000.
Dot Blot Dot: Use at an assay dependent dilution.

Target

  • FunctionPlays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
  • Tissue specificityExpressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
  • Sequence similaritiesBelongs to the heparin-binding growth factors family.
  • Post-translational
    modifications    Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
    Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
  • Cellular localizationSecreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

    • Target information above from: UniProt accession P09038 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
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  • Alternative names
      Basic fibroblast growth factor antibodyBasic fibroblast growth factor bFGF antibodyBFGF antibody
      FGF 2 antibodyFGF B antibodyFGF-2 antibodyFGF2 antibodyFGF2 basic antibodyFGF2_HUMAN antibodyFGFB antibodyFibroblast growth factor 2 (basic) antibodyFibroblast growth factor 2 antibodyHBGF 2 antibodyHBGF-2 antibodyHBGF2 antibodyHBGH 2 antibodyHBGH2 antibodyHeparin binding growth factor 2 precursor antibodyHeparin-binding growth factor 2 antibodyProstatropin antibody
    see all

References for Anti-FGF basic antibody (ab8881)

ab8881 has not yet been referenced specifically in any publications.

Publishing research using ab8881 ? Please let us know so that we can cite the reference in this datasheet

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We need to know the concentration of use of the following antibody in IHC:ab8881. Thanks and regards

Thank you for your enquiry. According to a published article (Am J Physiol Gastrointest Liver Physiol, Vol. 276, Issue 1, G249-G258, January 1999), this researcher states the following: "For immunohistochemical localization of mouse FGF-2, we incu...

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I have used a polyclonal rabbit anti-fgf made from the 1-24 amino acid sequence of bovine FGF using KLH as a carrier. I bought this antibody from a different source. I have found a lot of non-specific binding in my western blots and in immuno-staining of ...

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Mouse monoclonal to human bFGF -- ab181 -- may be of interest to you. We do not have any other information re. Rabbit polyclonal to FGF other than that which appears on the datasheet. I suggest that you review the datasheet for the monoclonal and let me k...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"