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Overview

  • Product nameAnti-FGF1 antibodySee all FGF1 primary antibodies ...
  • Description
    Mouse monoclonal to FGF1
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 46-155 of Human FGF1

Properties

Applications

Our Abpromise guarantee covers the use of ab58311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionThe heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro.
    • Sequence similaritiesBelongs to the heparin-binding growth factors family.
    • Cellular localizationSecreted. Cytoplasm. Cytoplasm > cell cortex. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1.

      • Target information above from: UniProt accession P05230 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Acidic fibroblast growth factor antibodyaFGF antibodyBeta endothelial cell growth factor antibody
          Beta-endothelial cell growth factor antibodyECGF antibodyECGF beta antibodyECGF-beta antibodyECGFA antibodyECGFB antibodyEndothelial Cell Growth Factor alpha antibodyEndothelial Cell Growth Factor beta antibodyFGF 1 antibodyFGF alpha antibodyFgf1 antibodyFGF1_HUMAN antibodyFGFA antibodyFibroblast Growth Factor 1 Acidic antibodyFibroblast growth factor 1 antibodyGLIO703 antibodyHBGF 1 antibodyHBGF-1 antibodyHBGF1 antibodyHeparin binding growth factor 1 antibodyHeparin binding growth factor 1 precursor antibodyHeparin-binding growth factor 1 antibody
        see all

      Anti-FGF1 antibody images

      • IHC-P - FGF1 antibody (ab58311)
        IHC-P - FGF1 antibody (ab58311)
        FGF1 antibody (ab58311) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human spleen.
      • Western blot - FGF1 antibody (ab58311)
        Western blot - FGF1 antibody (ab58311)
        Western blot against tagged recombinant protein immunogen using ab58311 FGF1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

      References for Anti-FGF1 antibody (ab58311)

      ab58311 has not yet been referenced specifically in any publications.

      Publishing research using ab58311 ? Please let us know so that we can cite the reference in this datasheet

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      Phone call reporting problems in identifying endogenously expressed FGF1 using ab58311 and ab18963 in ovarian cancer cell lines.

      I now have a bit more information to share with you. As discussed, Anti-FGF1 (ab58311) is raised against a fusion protein of FGF1 (with a well know purification tag) of ~45 kDa, and it is this fusion protein which has been expressed and detected in the we...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"