Anti-FGF10 antibody (ab90207)
- Product nameAnti-FGF10 antibodySee all FGF10 primary antibodies ...
- DescriptionGoat polyclonal to FGF10
- Tested applicationsWB, Indirect ELISA, Sandwich ELISA more details
- Species reactivityReacts with: Recombinant Fragment
Predicted to work with: Human
Highly pure (>98%) recombinant hFGF-10
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: PBS, pH 7.2
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab90207 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 23 kDa. To detect hFGF-10 by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hFGF-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.|
|Indirect ELISA||I-ELISA: Use a concentration of 0.5 - 2 µg/ml. To detect hFGF-10 by indirect ELISA (using 100 µl/well antibody solution) a concentration of 0.5 - 2.0 µg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hFGF-10.|
|Sandwich ELISA||sELISA: Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to FGF10 (ab71794) and Goat polyclonal to FGF10 (Biotin) (ab83439). Can be used as Capture antibody when paired with ab83439. For sandwich ELISA, use this antibody as Capture at 5µg/ml with ab71794 as Detection.|
- FunctionCould be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.
- Involvement in diseaseDefects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
- Sequence similaritiesBelongs to the heparin-binding growth factors family.
- Cellular localizationSecreted.
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Anti-FGF10 antibody images
References for Anti-FGF10 antibody (ab90207)
ab90207 has not yet been referenced specifically in any publications.