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Products:Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF
Overview
Product name
FGF21 protein
See all FGF21 products (11) ...
Protein description
Recombinant full length FGF21 protein (Human) MW 19.5 kDa, 182 amino acid residues.
Expression host
E. coli
Properties
Purity
>90% by SDS-PAGE
Purification notes
Greater than 90% by SDS-PAGE gel and HPLC analyses.
Form
Lyophilised
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Concentration
Concentration information loading...
Additional notes
Reconstituted FGF-21 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C.
Sequence notes
MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Research areas
Cancer >> Growth factors >> FGF
Signal Transduction >> Growth Factors/Hormones >> FGF
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54141 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Functional Studies
SDS-PAGE
Application notes
Biological Activity : FGF21, in the absence of betaKlotho, causes some thymidine uptake by BaF3 cells expressing FGF receptors.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
Sequence similarities
Belongs to the heparin-binding growth factors family.
Cellular localization
Secreted.
Target information above from: UniProt accessionQ9NSA1
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for FGF21 protein (ab54141)
ab54141 has not yet been referenced specifically in any publications.
Publishing research using ab54141? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"