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FGF4 protein (ab50131)

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Overview

Product name

FGF4 protein
See all FGF4 products (2) ...

Protein description

Recombinant fragment, corresponding to amino acids 25/206 of Human FGF4 with sequence GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL

Expression host

E. coli

Properties

Purity

>95% by SDS-PAGE

Purification notes

Greater than 95% by SDS-PAGE. Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Form

Lyophilised

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Concentration

Concentration information loading...

Sequence notes

GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL

Research areas

Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factors
Cancer >> Growth factors >> FGF
Signal Transduction >> Growth Factors/Hormones >> FGF
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF

Applications

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Our Abpromise guarantee covers the use of ab50131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    Functional Studies

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    FuncS: Use at an assay dependent dilution. (The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg. )

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    SDS-PAGE

     SDS-PAGE: Use at an ass...Read more →

    SDS-PAGE: Use at an assay dependent dilution.

Protein info

Function

Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Cellular localization

Secreted.

Target information above from: UniProt accessionP08620 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for FGF4 protein (ab50131)

ab50131 has not yet been referenced specifically in any publications.

Publishing research using ab50131? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"