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Products:Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF
Overview
Product name
Anti-FGF9 antibody [FG9-77]
See all FGF9 products (7) ...
Description
Mouse monoclonal [FG9-77] to FGF9
Specificity
Monoclonal Anti-FGF9 reacts specifically with recombinant FGF9 (fibroblast growth factor 9). It does not cross-react with human FGF Acidic and FGF Basic.
Tested applications
ELISA, Dot Blot, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Recombinant full length protein (Mouse).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
FG9-77
Isotype
IgG1
Research areas
Developmental Biology >> Reproduction >> Placental development
Developmental Biology >> Reproduction >> Sex determination
Neuroscience >> Neurology process >> Neuroregeneration >> Neuroregeneration
Neuroscience >> Neurology process >> Neurogenesis
Signal Transduction >> Growth Factors/Hormones >> FGF
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10424 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
Dot: Use a concentration of 5 µg/ml
WB: Use at an assay dependent dilution. Detects a band of approximately 25 kDa.
Target
Function
May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Tissue specificity
Glial cells.
Involvement in disease
Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3) [MIM:612961]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness.
Sequence similarities
Belongs to the heparin-binding growth factors family.
Post-translational
modifications
Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
N-glycosylated.
Cellular localization
Secreted.
Target information above from: UniProt accessionP31371
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- FGF 9 antibody
- FGF-9 antibody
- FGF9 antibody
see all
Database links
- Entrez Gene: 2254 Human
- Entrez Gene: 14180 Mouse
- Omim: 600921 Human
- SwissProt: P31371 Human
- SwissProt: P54130 Mouse
- Unigene: 111 Human
- Unigene: 8846 Mouse
References for Anti-FGF9 antibody [FG9-77] (ab10424)
ab10424 has not yet been referenced specifically in any publications.
Publishing research using ab10424? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"