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Anti-FGFR4 antibody (ab5481)

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Overview

Product name

Anti-FGFR4 antibody
See all FGFR4 products (6) ...

Description

Rabbit polyclonal to FGFR4

Tested applications

ELISA, WB, IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to amino acids 39-56 of Human FGFR 4.

Positive control

THP-1 cell lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.

Primary antibody notes

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Growth factors >> FGF
Stem Cells >> Neural Stem Cells >> Surface Molecules
Signal Transduction >> Growth Factors/Hormones >> FGF
Neuroscience >> Cell Type Marker >> Neural Stem Cell marker
Cardiovascular >> Angiogenesis >> Growth Factors >> FGF >> FGF Receptors

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FGFR4 antibody (ab5481)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FGFR4 antibody (ab5481) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab5481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

Tissue specificity

Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

Post-translational
modifications

Glycosylated.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.

Cellular localization

Membrane. Isoform 2 may be secreted.

Target information above from: UniProt accessionP22455 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD 334 antibody
  • CD334 antibody
  • CD334 antigen antibody
  • fc13h 10 antibody
  • fc13h10 antibody
  • Fgfr 4 antibody
  • FGFR-4 antibody
  • Fgfr4 antibody
  • FGFR4_HUMAN antibody
  • Fibroblast growth factor receptor 4 antibody
  • Hydroxyaryl protein kinase antibody
  • JTK 2 antibody
  • JTK2 antibody
  • MGC20292 antibody
  • Protein tyrosine kinase antibody
  • TKF antibody
  • Tyrosine kinase related to fibroblast growth factor receptor antibody
  • Tyrosylprotein kinase antibody
see all

Database links

Anti-FGFR4 antibody images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FGFR4 antibody (ab5481)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FGFR4 antibody (ab5481)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.

References for Anti-FGFR4 antibody (ab5481)

ab5481 has not yet been referenced specifically in any publications.

Publishing research using ab5481? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"