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Products:Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Overview
Product name
Anti-FHIT antibody
See all FHIT products (5) ...
Description
Rabbit polyclonal to FHIT
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human).
Positive control
Normal Breast
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab15287 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P
Application notes
IHC-P: 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
FHIT (fragile histidine triad) cleaves adenosine 5' PPP 5' A to yield AMP and ADP. Alterations and deletions of the FHIT gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach and pancreas. In normal cells, FHIT may act as a tumor suppressor. FHIT physically associates with ubiquitin conjugating enzyme 9.
Cellular localization
Cytoplasmic
Alternative names
- AP3A hydrolase antibody
- AP3A hydrolase fragile site 3p14.2 antibody
- AP3Aase antibody
see all
Database links
- Entrez Gene: 2272 Human
- Omim: 601153 Human
- SwissProt: P49789 Human
- Unigene: 655995 Human
References for Anti-FHIT antibody (ab15287)
This product has been referenced in:
- Czyzewska Jet al. Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time. Folia Histochem Cytobiol 47:47-53 (2009).Read more (PubMed: 19419937) »
See 1 publication for this product
Publishing research using ab15287? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"