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SDS-PAGE - FKBP12 protein (His tag) (ab61244)

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Product Name
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FKBP12 protein (His tag)
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Product type
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Proteins and Peptides
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Peptide
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Recombinant full length Human FKBP12 (FK506 binding protein 1A, transcript variant 12A) Swiss-Prot ID = P62942 (GenBank Accession No. NM_054014), containing an N-terminal His tag. MW 13.1 kDa. Expressed in Baculovirus infected Sf9 cell expression system.
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Tested applications
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Immunology >> Immune Interventions >> Transplantation
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Relevance
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.
This protein can be used for testing rapamycin inhibition of mTOR.
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Purity
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>90% by SDS-PAGE
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Storage buffer
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Preservative: None Constituents: 50% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM PMSF, 0.1mM EDTA, pH 7.5 Material safety datasheet (MSDS) for this product: Glycerol MSDS
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Form
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Liquid
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Concentration
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3.500 mg/ml
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Storage instructions
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Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this FKBP12 protein (His tag) is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for FKBP12 protein (His tag) images, references, products related to ab61244 and other tools.
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FKBP12 protein (His tag) images:
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SDS-PAGE - FKBP12 protein (His tag) (ab61244)
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Search PubMed (MEDLINE) for references to FKBP12
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FKBP12 protein (His tag) - more information
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