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FKBP12 protein (His tag) (ab61244)

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Overview

Product name

FKBP12 protein (His tag)
See all FKBP12 products (6) ...

Protein description

Recombinant full length Human FKBP12 (FK506 binding protein 1A, transcript variant 12A) Swiss-Prot ID = P62942 (GenBank Accession No. NM_054014), containing an N-terminal His tag. MW 13.1 kDa. Expressed in Baculovirus infected Sf9 cell expression system.

Properties

Purity

>90% by SDS-PAGE

Form

Liquid

Storage instructions

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 50% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

Concentration

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Research areas

Immunology >> Immune Interventions >> Transplantation

  • SDS-PAGE - FKBP12 protein (His tag) (ab61244)SDS-PAGE - FKBP12 protein (His tag) (ab61244) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab61244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Contains 1 PPIase FKBP-type domain.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionP62942 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

FKBP12 protein (His tag) images:

  SDS-PAGE - FKBP12 protein (His tag) (ab61244)

SDS-PAGE - FKBP12 protein (His tag) (ab61244)

References for FKBP12 protein (His tag) (ab61244)

ab61244 has not yet been referenced specifically in any publications.

Publishing research using ab61244? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"