Overview
- Product nameAnti-FKBP38 antibodySee all FKBP38 primary antibodies ...
- DescriptionRabbit polyclonal to FKBP38
- Tested applicationsIHC-P, WB more details
- Species reactivityReacts with: Mouse, Rat, Human
- Immunogen
Synthetic peptide from FKBP38 (Mouse) (Peptide available as ab51928.)
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: 20% Glycerol, 0.1% BSA, PBS -
Concentration information loading... - PurityProtein A purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab24450 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| IHC-P | IHC-P: Use at an assay dependent dilution. See Abreviews. |
| WB | WB: Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 38 kDa).Can be blocked with FKBP38 peptide (ab51928). |
Target
- FunctionConstitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
- Tissue specificityWidely expressed. Highest levels seen in the brain.
- Sequence similaritiesContains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats. - Cellular localizationMitochondrion membrane.
-
Database links
- Entrez Gene: 23770 Human
- Entrez Gene: 14232 Mouse
- Entrez Gene: 290652 Rat
- Omim: 604840 Human
- SwissProt: Q14318 Human
- SwissProt: O35465 Mouse
- SwissProt: Q3B7U9 Rat
- Unigene: 173464 Human
- Unigene: 141864 Mouse
- Unigene: 99789 Rat
see all
Target information above from: UniProt accession
Q14318
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
.
-
Alternative names
- 38 kDa FK 506 binding protein homolog antibody38 kDa FK506-binding protein antibody38 kDa FKBP antibody
- 38kDa antibodyFK506 binding protein 8 antibodyFK506 binding protein 8, 38kDa antibodyFK506 binding protein, 38kDa antibodyFK506-binding protein 8 antibodyFKBP 38 antibodyFKBP-38 antibodyFKBP-8 antibodyFKBP8 antibodyFKBP8_HUMAN antibodyFKBPR38 antibodyhFKBP38 antibodyPeptidyl-prolyl cis-trans isomerase FKBP8 antibodyPPIase FKBP8 antibodyRotamase antibodySam11 antibody
see all
Anti-FKBP38 antibody images
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FKBP38 antibody (ab24450)This image is courtesy of an Abreview submitted by Miss Gwen LagodaImmunohistochemical analysis of Human penile tissue, staining FKBP38 with ab24450.
Tissue was fixed with paraformaldehyde and blocked with blocking reagent for 2 hours; antigen retrieval was by heat mediation. Samples were incubated with primary antibody (1/1000 in diluent) for 18 hours. An undiluted HRP-conjugated anti-rabbit polyclonal IgG was used as the secondary antibody.
References for Anti-FKBP38 antibody (ab24450)
This product has been referenced in:
- Wiley M et al. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem 285:26852-60 (2010). WB ; Human . Read more (PubMed: 20581113) »
