Overview

  • Product nameAnti-FKBP38 antibodySee all FKBP38 primary antibodies ...
  • Description
    Rabbit polyclonal to FKBP38
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Non Human Primates
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human FKBP38.

    (Peptide available as ab99883.)

  • Positive control
    • This antibody gave a positive signal in Human and Mouse Liver Tissue Lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab90530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 38 kDa).Can be blocked with Human FKBP38 peptide (ab99883).

Target

  • FunctionConstitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
  • Tissue specificityWidely expressed. Highest levels seen in the brain.
  • Sequence similaritiesContains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.
  • Cellular localizationMitochondrion membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 38 kDa FK506-binding protein antibody
    • 38 kDa FKBP antibody
    • 38kDa antibody
    • FK506 binding protein 8 antibody
    • FK506 binding protein 8, 38kDa antibody
    • FK506 binding protein, 38kDa antibody
    • FK506-binding protein 8 antibody
    • FKBP 38 antibody
    • FKBP-38 antibody
    • FKBP-8 antibody
    • FKBP8 antibody
    • FKBP8_HUMAN antibody
    • FKBPR38 antibody
    • hFKBP38 antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP8 antibody
    • PPIase FKBP8 antibody
    • Rotamase antibody
    • Sam11 antibody
    see all

Anti-FKBP38 antibody images

  • Anti-FKBP38 antibody (ab90530) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 38 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)


    Exposure time : 20 minutes
  • Anti-FKBP38 antibody (ab90530) at 1 µg/ml + Liver (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 38 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 48 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 12 minutes

References for Anti-FKBP38 antibody (ab90530)

ab90530 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"