Anti-FKBP38 antibody (ab96322)

Overview

• Product nameAnti-FKBP38 antibodySee all FKBP38 primary antibodies ...
• Description
  Rabbit polyclonal to FKBP38
• Tested applicationsWB, ICC/IF more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Recombinant fragment, corresponding to a region within N terminal amino acids 1 - 276 of Human FKBP38.

• Positive control293T, A431, H1299, HeLa S3, HepG2, Molt-4, Raji or Hela cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Calcium Binding Proteins

  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Calmodulin Pathway

  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Other Chaperones

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Associated Proteins

Applications

Target

• FunctionConstitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
• Tissue specificityWidely expressed. Highest levels seen in the brain.
• Sequence similaritiesContains 1 PPIase FKBP-type domain.
  Contains 3 TPR repeats.
• Cellular localizationMitochondrion membrane.

Target information above from: UniProt accession Q14318 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 23770 Human
  • Entrez Gene: 14232 Mouse
  • Entrez Gene: 290652 Rat
  • Omim: 604840 Human
  • SwissProt: Q14318 Human
  • SwissProt: O35465 Mouse
  • SwissProt: Q3B7U9 Rat
  • Unigene: 173464 Human

  • Unigene: 141864 Mouse
  • Unigene: 99789 Rat

  see all

• Alternative names
  38 kDa FK506-binding protein antibody38 kDa FKBP antibody38kDa antibody

  FK506 binding protein 8 antibodyFK506 binding protein 8, 38kDa antibodyFK506 binding protein, 38kDa antibodyFK506-binding protein 8 antibodyFKBP 38 antibodyFKBP-38 antibodyFKBP-8 antibodyFkbp8 antibodyFKBP8_HUMAN antibodyFKBPR38 antibodyhFKBP38 antibodyPeptidyl-prolyl cis-trans isomerase FKBP8 antibodyPPIase FKBP8 antibodyRotamase antibodySam11 antibody

  see all

Anti-FKBP38 antibody images

• 

  Western blot - FKBP38 antibody (ab96322)
  All lanes : Anti-FKBP38 antibody (ab96322) at 1/5000 dilution
  
  Lane 1 : HeLa whole cell lysate
  Lane 2 : HepG2 whole cell lysate
  
  Lysates/proteins at 30 µg per lane.
  
  
  Predicted band size : 45 kDa
  
• 

  Immunocytochemistry/ Immunofluorescence - FKBP38 antibody (ab96322)
  Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab96322 at 1:200 dilution.